Adult cortical plasticity following injury: Recapitulation of critical period mechanisms?
نویسندگان
چکیده
منابع مشابه
Mechanisms of neural plasticity following brain injury.
Brain insults cause rapid cell death, and a disruption of functional circuits, in the affected regions. As the injured tissue recovers from events associated with cell death, regenerative processes are activated that over months lead to a certain degree of functional recovery. Factors produced by new neurons and glia, axonal sprouting of surviving neurons, and new synapse formation help to re-e...
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In contrast to the prenatal development of the cerebral cortex, when cell production, migration, and layer formation dominate, development after birth involves more subtle processes, such as activity-dependent plasticity that includes refinement of synaptic connectivity by its stabilization and elimination. In the present study, we use RNA-seq with high spatial resolution to examine differentia...
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Development of the cerebral cortex is influenced by sensory experience during distinct phases of postnatal development known as critical periods. Disruption of experience during a critical period produces neurons that lack specificity for particular stimulus features, such as location in the somatosensory system. Synaptic plasticity is the agent by which sensory experience affects cortical deve...
متن کاملPlasticity following injury to the adult central nervous system: is recapitulation of a developmental state worth promoting?
The adult central nervous system (CNS) appears to initiate a transient increase in plasticity following injury, including increases in growth-related proteins and generation of new cells. Recent evidence is reviewed that the injured adult CNS exhibits events and patterns of gene expression that are also observed during development and during regeneration following damage to the mature periphera...
متن کاملAdult Cortical Plasticity
Plasticity of the brain is a lifelong phenomenon. In general, cortical plasticity describes changes of neuronal wiring and function in the cerebral cortex in response to new challenges of external or internal origin. External stimuli are environmental conditions that impose new tasks on the system. Internal stimuli can be normal developmental demands or pathological lesions in the widest sense ...
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ژورنال
عنوان ژورنال: Neuroscience
سال: 2014
ISSN: 0306-4522
DOI: 10.1016/j.neuroscience.2014.04.029